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Effects of the α2-adrenoceptor agonist xylazine, in the presence of vehicle (veh) or the α2-adrenoceptor antagonist BRL 44408 1 μM (BRL, α2D-selective), on isometric contractions evoked by 10 Hz electrical stimulation for 4 s in vas deferens from wild-type (WT) or α2A/D-adrenoceptor knockout (ko) mice in the presence of cocaine (3 μM). Vertical bars indicate s.e. of mean from at least four experiments.
