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Effects of p38 and MEK1/2 inhibition on LPS-induced TNF-α release from mouse macrophages. Cells were pretreated for 1 h with vehicle (DMSO), SB203580 (SB) or PD98059 (PD) at the indicated concentration or a combination of SB plus PD (2.5 μM and 10 μM). At the end of pretreatment, macrophages were challenged with LPS (10 ng ml−1) for 24 h and media collected and processedas described in the Methods section. Data are presented as means±s.e.mean; n=11; *P<0.05 from LPS.
