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. 2002 Aug;136(7):1015–1022. doi: 10.1038/sj.bjp.0704805

Figure 6.

Figure 6

Original tracings illustrating the effects of maximally effective concentration of LOE 908 (A) and SK&F 96365 (B) on the ET-1-induced sustained increase in [Ca2+]i in CHO-ETBR pretreated with U73122. The cells loaded with fluo-3 were incubated with 5 μM U73122 for 10 min before 10 nM ET-1 stimulation. After [Ca2+]i reached a steady-state, 10 μM LOE 908 or 10 μM SK&F 96365 was added at the time indicated by horizontal bars. (C) Effects of maximally effective concentration of LOE 908 and SK&F 96365 on the ET-1-induced sustained increase in [Ca2+]i in CHO-ETBR pretreated with U73122. The experimental protocols were described in Methods, and the values of [Ca2+]i following addition of 10 μM LOE 908 or 10 μM SK&F 96365 were determined. Each point represents the mean±s.e.m. of five experiments.