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OFQ/N reduces spontaneous IPSPs in VTA dopamine neurons. (A) OFQ/N (300 nM) attenuates the frequency of bicuculline (30 μM)- and TTX (0.5 μM)-sensitive spontaneous IPSPs in a dopamine neuron. Dashed line indicates −70 mV. Note hyperpolarization induced by OFQ/N. (B) Histogram shows the distribution of IPSP amplitude of this neuron during control and OFQ/N application. In each condition, data are collected for 30 s and events are binned in 0.5 mV intervals.
