Figure 1.

Effects of bradykinin and substance P on open probability, number of openings and mean open time of SK_ap-ins channel. Results were obtained on the same cell during successive applications of substance P (100 nM) and bradykinin (100 nM), perfused in the bath during the time indicated by the bar. During recording the holding potential was maintained at 0 mV. (A) Original current traces in cell-attached configuration at a holding potential of 0 mV: (a), (b), shows the activation induced by substance P (horizontal bar); (c), (d) during the perfusion of bradykinin (horizontal bar). (B,C,D) Open state probability (P_o), number of openings (N) and mean open time (τ) are expressed versus the time of peptide application.