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Effect of increasing doses of rofecoxib (0, 1, 3, 10 and 30 mg kg−1 d−1) on the release of PGE2 into inflammatory exudate, on whole blood TxB2 synthesis and gastric PGE2. Rats were pre-treated with rofecoxib 30 min before injection of carrageenan (2 ml of a 1% wt vol−1 solution in sterile saline) into the air-pouch. Data represent the mean±s.e.mean of n=4–5 rats. Asterisk indicates significance of control rats to rofecoxib treated rats.
