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Development of systolic blood pressure of WKY rats treated with vehicle or rofecoxib at increasing doses (1, 3, 10 and 30 mg kg−1 d−1) for 4 weeks during normal salt intake (0.6%, wt wt−1). Data represent the mean±s.e.mean of n=8 rats. Asterisk indicates significance of control rats to rofecoxib treated rats.
