Skip to main content
. 2002 Sep;137(1):87–97. doi: 10.1038/sj.bjp.0704832

Figure 8.

Figure 8

Action of cortisol on recombinant hKv1.1 potassium channels. (A) Illustration of the voltage protocol used; cells were held at −80 mV and stepped to command potentials in the range of −120 mV to +60 mV, in 10 mV increments. Up to 20 s was allowed between each pulse for recovery of inactivation. (C) A family of hKv1.1 potassium currents recorded under control conditions. (C) A family of hKv1.1 potassium currents recorded in the presence of 10 μM cortisol. (D) Mean normalized Boltzmann curves from a number of experiments similar to those shown in (B) & (C). (E) Neither 1 μM or 10 μM cortisol caused significant alteration in midpoint parameters. Control V1/2 −30.0±2.6 mV, k 8.4±1.2 mV, maximum 4.8±1.9 nS (n=8). 1 μM cortisol: V1/2 −30.4±3.3 mV, k 7.1±1.0 mV, maximum 2.0±0.9 nS (n=5). 10 μM cortisol: V1/2 −28.9±1.8 mV, k 8.0±1.2 mV, maximum 5.1±1.1 nS (n=5). 24°C Pipette solution III, bath solution VI (Table 1).