Figure 3.

Effect of intraperitoneal injection of 0.3 nmol of orexin-A and saline on the time course of the flinches observed after formalin injection into the dorsal surface of the right rat hind-paw. Drugs were administered intraperitoneally 10 min before the formalin injection. The number of flinches/min is plotted vs time after the formalin injection. Each line represents the group mean and s.e.m. of five rats. Intraperitoneal injection of 0.3 nmol of orexin-A had no effect on the formalin test as compared with saline treated rats.