Figure 7.

Changes in airway reactivity to inhaled acetylcholine 24 h after single (A) or multiple (B) antigen challenge and to inhaled bradykinin (C) 24 h after both single and multiple challenge in the Brown Norway rat. Antigen (ovalbumin)-sensitized Brown Norway rats were either unchallenged (open bars), exposed to inhaled saline (sham challenged, shaded bars) or challenged with inhaled antigen aerosol (solid bars). Animals were challenged with saline or ovalbumin once or once daily for six consecutive days. Group size was 7–8. Results are mean±s.e.mean.