Figure 3.
Effects of vehicle, NCX 4016, NCX 4023, aspirin and salicylic acid on the release of 6-keto-PGF1α (upper panel) from perfused rat tail arteries submitted to 8 Hz transmural nerve stimulation (TNS) (lower panel). Drugs were perfused through the arteries for 15 min and the related perfusates were collected at the end of 15 min for 6-keto-PGF1α determination. Values are means±s.e.mean, n=8 different arteries per group. 8 Hz TNS-elicited 6-keto-PGF1α formation was significantly inhibited by NCX 4016 and aspirin (*P<0.05, **P<0.01, ***P<0.001 compared to vehicle-treated preparations).