Cyclic GMP-tissue accumulation (upper panel) during maximal (1 min) vasorelaxant response (lower panel) induced by bolus injection of vehicle, NCX 4016, NCX 4023, sodium nitroprusside (SNP) and acetylcholine (ACh) in perfused rat tail arteries precontracted with norepinephrine (30 nM). Values are means±s.e.mean, n=8 different arteries per group. **P<0.01 and **P<0.001 compared to vehicle-treated preparations. #P<0.05 compared to NCX 4016, SNP and ACh-treated preparations.