Figure 2.

FDP attenuates UVB-induced COX activity. HaCaT keratinocytes that had been pretreated with aspirin (100 μM for 30 min were exposed to UV irradiation (30 mJ cm⁻²). After the UVB exposure, cells were incubated with FDP or NAC (20 mM) in fresh culture media containing 10% FCS for 24 h. COX activity was determined as described in Methods. The results are expressed as mean±s.e.mean in three different experiments. UVB-irradiation significantly increased COX activity compared with unirradiated control (#P<0.01). A significant difference in COX activity relative to UVB control is indicated with ^*P<0.05 or ^**P<0.01.