Figure 1.

Effect on oedema of palmitoylethanolamide (PEA) 10 mg kg⁻¹ and indomethacin (ID) 5 mg kg⁻¹, p.o. in the rat after the onset of inflammation. (a) Time-course of the inhibition of oedema by PEA and ID on the first day of treatment (time zero represents paw volume evaluation 2 h after carrageenan or saline). (b) Inhibitory effect of PEA and ID during treatment (day 1 represents paw volume evaluation 2 h after carrageenan or saline). Each point represents the mean±s.e.mean of 8–12 animals. ^°P<0.05 vs non-inflamed; ^*P<0.05 vs inflamed/vehicle.