Figure 4.

No effect of Aβ_1–42 pretreatment on PPF, basal synaptic response and maximum fEPSP amplitude in hippocampal slices. (A) PPF in control slices (open circles; n=5), and slices pretreated with 1 μM Aβ_1–42 for 5 h (closed circles; n=5). (B) The time course of basal synaptic response in control slices (open circles; n=4), and slices pretreated with Aβ_1–42 (closed circles; n=4). HFS was not applied during the measurement. (C) The maximum fEPSP amplitude before the measurement of LTP. Control: control slices, Aβ_1–42: slices pretreated with 1 μM Aβ_1–42, RS-0406: slices pretreated with 3 μg ml⁻¹ RS-0406, and Aβ_1–42+RS-0406: slices pretreated with 1 μM Aβ_1–42 and 3 μg ml⁻¹ RS-0406 (n=5–6).