Figure 5.

Number of colony-forming units (CFU) after infection with K. pneumoniae (A) after the pre-treatment with the PAF receptor antagonist UK 74,505 or in (B) PAFR^−/− mice. Animals were inoculated with 3×10⁶ bacteria or vehicle (30 μl) and the number of CFU in lung homogenates evaluated after 24 h. PAFR^−/− mice were compared to their respective wild-type controls. Results are shown as the mean±s.e.mean of five animals in each group. *P<0.01 when compared with animals treated with vehicle-treated wild-type controls.