Figure 6.

Role of the PAF receptor for the survival of animals after infection with K. pneumoniae. Four groups of animals were evaluated (eight animals in each group): infected animals (inoculated with 3×10⁶ bacteria) which were PAF receptor-deficient (PAFR^−/−), wild-type (Infected WT) or wild-type treated with the PAF receptor antagonist UK 74,505 (WT+UK 74,505) and animals which received only vehicle (30 μl, not infected). The number of dead animals was evaluated every 12 h and results are shown as per cent survival. Survival of PAFR^−/− and UK 74,505-treated animals was significantly different from that of infected WT animals (P<0.05).