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Effect of 7-ketocholesterol on ACh- and A23187-mediated endothelium-dependent relaxation of rabbit aorta. Graphs show concentration-response curves to ACh (A) and A23187 (B) of arteries precontracted with 0.3 μM NE and preincubated for 2 h without (control) or with (7-keto) 90 μg ml−1 of 7-ketocholesterol. Each point represents the mean±s.e.mean of 5–8 distinct experiments. Significantly different from control: aP<0.05, bP<0.001.
