Figure 5.

Effect of glutathione on 7-ketocholesterol-induced inhibition of endothelium-dependent relaxation to ACh. Graph shows concentration-response curves to ACh of arteries precontracted with 0.3 μM NE and preincubated for 2 h without (control) or with (7-keto) 90 μg ml⁻¹ of 7-ketocholesterol. Glutathione (5 mM) was subsequently added 30 min before the contraction/relaxation cycle was performed. Each point represents the mean±s.e.mean of six distinct experiments. Significantly different from control: ^aP<0.05, ^bP<0.01.