Figure 4.

Ion currents evoked by capsaicin and gingerols in whole-cell patch clamped DRG neurones. (A) Voltage ramp was applied to patch-clamped DRG neurons in the presence of 10 μM capsaicin, 30 μM [8]-gingerol and 300 μM [6]-gingerol. Note the same I/V characteristics for all three drugs. (B) Ion current dose response to capsaicin, [8]-gingerol, [6]-gingerol and zingerone calculated as percentage to the amplitude of current evoked by 10 μM capsaicin. Data are presented as mean±s.d of at least six neurones per data point.