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Effects of the selective COX-2 inhibitor, SC-236, on rat paw hyperalgesia and oedema. In (a) the hyperalgesia was totally prevented by the lower dose (1 mg kg−1) and a marked hypoalgesia induced by the higher dose of SC-236 (12 mg kg−1). In (b) neither dose reduced oedema. *Significantly different from carrageenan only; #significantly different from zero; P<0.05.
