Figure 6.

Intraplantar injection of celecoxib. In these experiments, celecoxib (300 μg) was given locally, i.e., into the footpad, 30 min before the carrageenan. Hyperalgesia was completely prevented and the nociceptive threshold raised above normal for at least 4 h, returning to baseline by 24 h. In (b) no moderation of the oedema was observed throughout the 24 h. *Significantly different from corresponding value for carrageenan; #significantly greater than zero time value; P<0.05.