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. 2002 Oct 30;137(6):861–873. doi: 10.1038/sj.bjp.0704941

Figure 1.

Figure 1

Diagrams illustrating the experimental protocols used to investigate: (a) the effects of drug or vehicle applied i.c. or i.v. on the cardiorespiratory responses evoked alternately by stimulating cardiopulmonary afferents with PBG and electrical stimulation of the aortic nerve afferents at increasing frequencies. In some experiments (shaded) the effects of buspirone were tested following intravenous pre-treatment with the 5-HT1A receptor antagonist WAY-100635. (b) the effects of drug or vehicle applied i.c. or i.v. on the cardiorespiratory responses evoked alternately by stimulating cardiopulmonary afferents with PBG and the carotid chemoreceptors with sodium cyanide (NaCN). In some experiments (shaded) the effects of buspirone were tested following pre-treatment with the 5-HT1A receptor antagonist WAY-100635 i.v. (c) the effects of the 5-HT1A receptor antagonist WAY-100635 applied i.c. on the cardiorespiratory responses evoked alternately by electrical stimulation of aortic nerve afferents and cardiopulmonary afferents with PBG or carotid chemoreceptors with sodium cyanide (NaCN).