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Concentration-effect curves (A) to the different 5-HT receptor agonists 5-HT, 5-CT, α-methyl-5-HT and 8-OH-DPAT obtained on mouse tracheal segments and (B) to 5-HT in absence and presence of 0.3, 1 and 3 nM of ketanserin, cultured for 4 days presence of 100 ng ml−1 TNFα. (C) Schild analysis of ketanserin. Each point represents the mean of all segments tested with error bars representing s.e.mean from six animals.
