Figure 2.

Concentration-dependent effects of butaprost, iloprost and sulprostone to alter the peristaltic pressure threshold (A), residual baseline pressure (B), maximal pressure (C) and maximal acceleration (D) of the peristaltic waves. The concentration–response curves were recorded in a cumulative manner at 15 min intervals. The values represent means+s.e.mean, n=12 for butaprost, n=13 for iloprost, n=16 for sulprostone. *P<0.05 versus parameters recorded immediately before drug administration when the drug concentration was ‘0' (ANOVA for repeated measures followed by Dunnett's test).