Figure 6.

Concentration-dependent effect of leukotriene D₄ (LTD₄) to alter the peristaltic pressure threshold (A), residual baseline pressure (B), maximal pressure (C) and maximal acceleration (D) of the peristaltic waves as assessed in the presence of vehicle (n=7) and tomelukast (n=7). The concentration–response curves were recorded in a cumulative manner at 15 min intervals. The values represent means+s.e.mean. *P<0.05 versus parameters recorded immediately before addition of LTD₄ as indicated by ‘0' (ANOVA for repeated measures followed by Dunnett's test).