Figure 4.

Ventricular fibrillation (VF; %) during a 25 min coronary artery occlusion (VF occlusion), following reperfusion (VF reperfusion) and survival following the combined ischaemia-reperfusion insult in control dogs (C), in preconditioned dogs (PC), in dogs given diazoxide (D), and in preconditioned dogs given 5-HD either prior to, or immediately after, the preconditioning occlusion. The reduction in VF and the increase in survival following ischaemic preconditioning is prevented by the administration of 5-HD prior to preconditioning. *P<0.05 compared to controls; #P<0.05 compared to preconditioned dogs.