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Changes in epicardial ST-segment elevation (mV) during a 25 min coronary artery occlusion in control (C) dogs, in preconditioned dogs (PC), in preconditioned dogs given 5-HD before (5-HD+PC) or after (PC+5-HD) preconditioning, and in dogs treated with diazoxide alone (D) or in the presence of 5-HD (5-HD+D). The preconditioning and diazoxide-induced reductions in this index of ischaemia severity are prevented by 5-HD. Values are means±s.e.mean. *P<0.05 compared to control.
