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. 2002 Nov 27;137(8):1362–1370. doi: 10.1038/sj.bjp.0704960

Figure 3.

Figure 3

Effects of 20-HETE and iberiotoxin on whole-cell K+ current. (A) Effect of 20-HETE. Upper panel, representative tracings of outward whole-cell K+ current elicited by depolarizing pulses to +60 mV from a holding potential of −70 mV in the absence or presence of 30 nM or 100 nM 20-HETE. Lower panel, current-voltage relationships of whole-cell K+ current for the same cell shown in the upper panel in the absence or the presence of 30 nM or 100 nM 20-HETE. Whole-cell K+ current was activated by incremental 10 mV depolarizing steps from a holding potential of −70 mV to +60 mV. (B) Effect of iberiotoxin. Upper panel, representative tracings of outward whole-cell K+ current elicited by depolarizing pulses to +60 mV from a holding potential of −70 mV in the absence or presence of 100 nM iberiotoxin or 100 nM 20-HETE plus 100 nM iberiotoxin. Lower panel, current-voltage relationships of whole-cell K+ current for the same cell shown in the upper panel in the absence or the presence of 100 nM iberiotoxin or 100 nM 20-HETE plus 100 nM iberiotoxin. Each point represents the mean±s.e.mean of five experiments.