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. 2002 Nov 27;137(8):1269–1279. doi: 10.1038/sj.bjp.0704978

Figure 7.

Figure 7

Apparent voltage dependence of channel availability. The pulse protocol used to obtain each data point is shown in the top of the Figure. (a) original traces obtained after applying such pulse protocol in the absence and in the presence of 20 μM bupivacaine. The peak current observed immediately after stepping to +30 mV was then plotted vs the test potential. Currents were recorded in the absence and in the presence of 20 μM of levobupivacaine (b), ropivacaine (c) and bupivacaine (d). Currents decreased at negative potentials due to deactivation during the 20 ms pulse. Left panels show non-corrected data and right panels show corrected data for deactivation (see Results). Each point represents the mean±s.e.mean of 4–5 experiments. The dashed lines represent the normalized fits to matching control. *P<0.05.