Figure 5.

Areas under the curves (AUC, g×min, means±s.e.m.) of the respective time-course curves in Figures 2,3,4 (open bars) and effect of pretreatment with GR 127935 (3 mg kg⁻¹, s.c. 20 min before, hatched bars) on mechanical response thresholds in the infraorbital nerve territory ipsilateral and contralateral to the ligature after administration of dihydroergotamine (DHE, 50 μg kg⁻¹, i.v.), sumatriptan (Suma, 100 μg kg⁻¹, s.c.) or zolmitriptan (Zolmi, 100 μg kg⁻¹, s.c.). **P<0.01, ***P<0.001 versus saline, ^•P<0.05, ^•••P<0.001 versus treatment with DHE, sumatriptan or zolmitriptan alone, n=6 in each group.