Figure 6.
Effect of pretreatment with WAY 100635 (2 mg kg−1, s.c., 20 min before) on dihydroergotamine (DHE, 50 μg kg−1, i.v.)-induced changes in the mechanical response thresholds in the infraorbital nerve territory ipsilateral or contralateral to the ligature. Results are expressed as (A) the time-course curves of the mean±s.e.m., in grams, of the response thresholds and (B) the mean±s.e.m. of areas under the time-course curves (AUC) calculated by the trapezoidal rule (see Methods). •P<0.05, •••P<0.01 versus saline; *P<0.05 versus DHE (50 μg kg−1, i.v.) alone, n=6 in each group.