Figure 5.
Effect of combined administrations of PAF (UK-74,505) and LTB4 (CP-105,696) receptor antagonists on IL-1β-induced leukocyte adhesion and transmigration in mouse cremasteric venules. Mice were pretreated with CP-105,696 (100 mg kg−1, p.o., 19 h prior to the intrascrotal injection of saline or 30 ng IL-1β), UK-74,505 (0.5 mg kg−1 i.v., 10 min prior to intrascrotal injection of saline or 30 ng IL-1β), or both antagonists. The results are presented as percentage inhibition of leukocyte adhesion (a) and transmigration (b) as compared to responses obtained in animals treated with appropriate vehicles and intrascrotal IL-1β, following subtraction of responses detected in mice treated with intrascrotal saline. Values represent mean±s.e.mean from n=5 mice per group. Statistically significant difference (one-way ANOVA and Newman-Keuls post-test) from vehicle treated groups is shown by asterisks, *P<0.05.