Figure 6.

Effects of xestospongin-C on outward K⁺ currents recorded from ileal smooth muscle cells. The cells were held at −60 mV, and test depolarisation with a duration of 900 ms was applied from −40 to +50 mV in increments of 10 mV. A pipette containing 0.05 mM EGTA was used to record currents. (A) Effect of 1 μM xestospongin-C on whole-cell currents. Summarized data on the effects of xestospongin-C (0.03–3 μM) at various concentrations on whole-cell currents (n=6) are presented in (B), in which cells had been pretreated with xestospongin-C for 10 min.