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Effect of PAR-selective peptides on (a) GM-CSF levels and (b) cell number. Quiescent cells were stimulated for 48 h with either thrombin (0.3 U ml−1) or one of the PAR-selective peptides (SFLLRN, PAR1, 10 μM; SLIGKV, PAR2, 10 μM; GYPGQV, PAR4, 100 μM). **P<0.01 and ***P<0.001 compared with basal, n=8. †P<0.05, compared with Thr. The average number of unstimulated cells (basal) at the end of the 48 h incubation was 2.0±0.3×105 cells per well.
