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Desensitisation of PAR1-stimulated increase in intracellular Ca2+ levels. Cells were exposed to the indicated agonists at intervals of 1 min without intervening washes. (a) A trace representative of four different cell culture preparations. Grouped data (n=4) showing desensitization of (b) thrombin- or (c) SFLLRN-induced increase in calcium levels. NS, not significant, †P<0.05, compared with original response.
