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. 2003 Mar 7;138(5):767–774. doi: 10.1038/sj.bjp.0705114

Figure 3.

Figure 3

Influence of WIN 55,212-2 (1 μmol kg−1) and CP 55940 (1 μmol kg−1) on the phenylbiguanide-induced von Bezold–Jarisch reflex in urethane-anaesthetized rats pre-treated with SR 141716A (3 μmol kg−1) and propranolol (0.3–0.4 μmol kg−1). Phenylbiguanide (3–10 μg kg−1) was injected i.v. every 10 min until three subsequent heart rate responses remained constant (S1A–C). Five minutes later a single dose of the cannabinoid receptor agonist under study was administered i.v. The reflex decrease in heart rate was induced again 10, 20 and 30 min following exposure to the respective cannabinoid receptor agonist (S2, S3 and S4). The S1A–C and S2–4 values were calculated as percentages of the basal heart rate immediately before the injection of phenylbiguanide. S2, S3 and S4 were then calculated as ratios over S1, where S1 is the mean of three subsequent comparable responses (S1A, S1B and S1C). Results are expressed as the percentage of the control receiving the respective vehicle. Mean±s.e.mean of n=4–11 rats. **P<0.01 compared to the corresponding control.