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Neurosteroid responses of UNC-49B and UNC-49B/C. (A) Pregnanolone inhibited both the UNC-49B homomer (upper traces) and the UNC-49B/C heteromer (lower traces). (B) Alphaxalone inhibited GABA-evoked currents in oocytes expressing UNC-49B/C heteromers. GABA concentrations corresponded to the EC50 value for each receptor, bars above traces represent duration of drug exposure.
