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Bicuculline does not affect UNC-49 receptors. UNC-49B homomers (upper traces) and UNC-49B/C heteromers (lower traces) were exposed to GABA (left), or GABA plus 10 μM bicuculline (right). The increased current rise time in the UNC-49B homomer trace shown is not consistently observed. Bars above traces indicate the duration of drug application. GABA concentrations corresponded to the respective EC50 values. GABA-only traces are the same as shown in Figure 1.
