Figure 2.

Pretreatment with nafamostat mesilate abolishes the ioxaglate-induced pulmonary oedema and increase in tissue Na⁺ content in the rat lung. Nafamostat mesilate (10 mg kg⁻¹) was injected i.v. 5 min before intravenous injection of ioxaglate (4 g iodine kg⁻¹). Lungs were dissected 10 min after ioxaglate injection. Pulmonary oedema was assessed by tissue water content. Each column represents the mean±s.e.mean for n=4–6 experiments. ^*P<0.05 versus control; ^†P<0.05 versus ioxaglate alone.