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Actin stress fibres increase, while VE-cadherin immunoreactivity decreases after exposure of cultured HPAECs to ioxaglate (100 mg iodine ml−1), ioxaglate+mast cells, and tryptase (7×10−3 units ml−1). The increase in actin stress fibres and the decrease in VE-cadherin induced by ioxaglate+mast cells or tryptase are blocked by nafamostat mesilate (1 nM).
