Table 5.

Simulations of agonist binding and receptor activation using the Ternary Complex Model

Simulation 1
				log KAG
	8	7.522	7	6.699	6.522	6.301	6
%Emax	99	97	91	85	80	72	58
EC50	682	1985	6014	10,780	14,800	21,340	33,050
Kl/Kh	152.9	54.8	19.0	10.9	7.9	5.5	3.5
Kl	89,580	88,190	86,650	86,980	88,080	89,330	91,360
Kl/EC50	131.3	44.4	14.4	8.1	6.0	4.2	2.8
Simulation 2
				log KA
	3.903	4.477	4.903	5.176	5.398	5.602	5.903	6.301
%Emax	99	97	93	88	82	75	63	43
EC50	684	661	616	566	514	456	361	237
Kl/Kh	189	54.7	23.1	13.6	9.1	6.4	3.9	2.4
Kl	113,100	29,200	108,20	5841	3530	2214	1161	467
Kl/EC50	165	44.2	17.6	10.3	6.9	4.9	3.2	2.0

Simulations were performed for the Ternary Complex Model as described in the Methods section and in the legend to Figure 6. Values for K_l and K_h were determined from simulated ligand binding data, and values for EC₅₀ and E_max were determined from simulated response data. K_l and EC₅₀ are given in nM.