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Concentration–response curves to noradrenaline following prazosin (0.1 μM) (praz) or prazosin (0.1 μM)/yohimbine (1 μM) (praz/yoh) in vas deferens from wild-type (WT) and α2A/D-adrenoceptor knockout mice (ko) in the second series of experiments. Vertical bars indicate s.e.m. from eight to 11 animals. The response to noradrenaline (10 μM) following prazosin in wild-type was significantly larger than in the other three groups.
