Table 1.
Effects of antagonists on potency (pD2, −log M) and maximum contraction (g) of noradrenaline in vas deferens from wild-type and α2A/D-adrenoceptor knockout mice
| Wild-type | Knockout | |||
|---|---|---|---|---|
| pD2 | max (g) | pD2 | max (g) | |
| Vehicle | 6.06±0.23 | 0.318±0.038 | 6.13±0.22 | 0.160±0.020* |
| Prazosin (0.1 μM) | 5.00±0.17** | 0.320±0.035 | 4.73±0.11** | 0.236±0.045 |
| Praz/yoh | 4.59±0.13** | 0.329±0.039 | 4.74±0.09** | 0.216±0.032* |
| RS 100329 (10 nM) | 5.30±0.20** | 0.110±0.029** | — | — |
Values are mean±s.e.m., from six to 11 (wild-type) or seven to eight (knockout) experiments.Abbreviations: praz/yoh, prazosin (0.1 μM)/yohimbine (1 μM).
*
P<0.05 versus equivalent wild-type
**
P<0.05 versus equivalent vehicle.