Table 2.
Infarct size | ||||
---|---|---|---|---|
Before operation | Sham operation | Small (<40%) | Large (>40%) | |
BW(g) | ||||
Untreated | 244±3 | 304±13 | 295±6 | 303±6 |
AM-251 | 245±3 | 292±6 | 300±5 | 307±10 |
HU-210 | 242±2 | 270±17 | 266±9†,## | 271±3# |
LVW/BW(g kg−1) | ||||
Untreated | 2.49±0.14 | 2.48±0.05 | 2.56±0.13 | |
AM-251 | 2.58±0.21 | 2.53±0.08 | 2.60±0.05 | |
HU-210 | 2.72±0.12 | 2.73±0.11 | 2.68±0.18 | |
RVW/BW(g kg−1) | ||||
Untreated | 0.50±0.06 | 0.80±0.07 | 1.11±0.11** | |
AM-251 | 0.63±0.06 | 0.80±0.11 | 1.20±0.10* | |
HU-210 | 0.54±0.05 | 0.67±0.05 | 1.23±0.11*** | |
LungW(g) | ||||
Untreated | 1.28±0.08 | 1.92±0.21 | 2.57±0.28** | |
AM-251 | 1.47±0.14 | 2.19±0.29 | 3.02±0.20** | |
HU-210 | 1.29±0.06 | 1.61±0.24 | 2.89±0.38* |
*P<0.05, **P<0.01, ***P<0.001 vs sham-operated rats in the same treatment groups.
P<0.05 vs untreated rats with comparable infarct size.
#P<0.05, ##P<0.01 HU-210 vs AM-251 rats with comparable infarct size.
Data presented are mean value ± s.e.m. BW = body weight; LVW=left-ventricular weight; RVW=right-ventricular weight; LungW = lung weight.