Table 4.

Cardiac performance after thoracotomy

	Infarct size
	Sham operation	Small (<40%)	Large (>40%)
Baseline:
MAP (mmHg)
Untreated	103±9	95±3	85±3*
AM-251	109±22	97±5	79±3
HU-210	110±6	108±4	104±9†,##
HR (beats min−1)
Untreated	353±18	334±11	334±18
AM-251	328±23	354±18	323±9
HU-210	357±14	370±15	354±21
CI (ml min−1 kg−1)
Untreated	218±16	185±18	176±13*
AM-251	303±59	182±14*	181±12**
HU-210	325±28	293±17††,##	203±19**
SVI (ml kg−1)
Untreated	0.62±0.03	0.56±0.06	0.54±0.04
AM-251	0.93±0.20	0.53±0.06*	0.57±0.04*
HU-210	0.91±0.07	0.80±0.05†,#	0.57±0.04**
TPRI (mmHg ml−1 min−1 kg−1)
Untreated	0.47±0.01	0.56±0.07	0.50±0.03
AM-251	0.42±0.16	0.55±0.04	0.46±0.04
HU-210	0.36±0.05	0.37±0.03†,#	0.52±0.05*
Aortic occlusion:
Dev Pmax (mmHg)
Untreated	215±4	177±12	143±8***
AM-251	236±13	159±12**	115±7***,†
HU-210	218±15	183±9	146±9**,#

^*P<0.05, ^**P<0.01, ^***P<0.001 vs sham-operated rats in the same treatment groups.

^†P<0.05, ^††P<0.01 vs untreated rats with comparable infarct size.

^#P<0.05, ^##P<0.01 HU-210 vs AM-251 rats with comparable infarct size.

Data presented are mean value ± s.e.m. Dev P_max=maximal developed pressure; for other abbreviations see extra list.