Table 4.
Infarct size | |||
---|---|---|---|
Sham operation | Small (<40%) | Large (>40%) | |
Baseline: | |||
MAP (mmHg) | |||
Untreated | 103±9 | 95±3 | 85±3* |
AM-251 | 109±22 | 97±5 | 79±3 |
HU-210 | 110±6 | 108±4 | 104±9†,## |
HR (beats min−1) | |||
Untreated | 353±18 | 334±11 | 334±18 |
AM-251 | 328±23 | 354±18 | 323±9 |
HU-210 | 357±14 | 370±15 | 354±21 |
CI (ml min−1 kg−1) | |||
Untreated | 218±16 | 185±18 | 176±13* |
AM-251 | 303±59 | 182±14* | 181±12** |
HU-210 | 325±28 | 293±17††,## | 203±19** |
SVI (ml kg−1) | |||
Untreated | 0.62±0.03 | 0.56±0.06 | 0.54±0.04 |
AM-251 | 0.93±0.20 | 0.53±0.06* | 0.57±0.04* |
HU-210 | 0.91±0.07 | 0.80±0.05†,# | 0.57±0.04** |
TPRI (mmHg ml−1 min−1 kg−1) | |||
Untreated | 0.47±0.01 | 0.56±0.07 | 0.50±0.03 |
AM-251 | 0.42±0.16 | 0.55±0.04 | 0.46±0.04 |
HU-210 | 0.36±0.05 | 0.37±0.03†,# | 0.52±0.05* |
Aortic occlusion: | |||
Dev Pmax (mmHg) | |||
Untreated | 215±4 | 177±12 | 143±8*** |
AM-251 | 236±13 | 159±12** | 115±7***,† |
HU-210 | 218±15 | 183±9 | 146±9**,# |
*P<0.05, **P<0.01, ***P<0.001 vs sham-operated rats in the same treatment groups.
†P<0.05, ††P<0.01 vs untreated rats with comparable infarct size.
#P<0.05, ##P<0.01 HU-210 vs AM-251 rats with comparable infarct size.
Data presented are mean value ± s.e.m. Dev Pmax=maximal developed pressure; for other abbreviations see extra list.