Table 2.
Effects of cannabinoid receptor antagonists on relaxation to abn-cbd in endothelium-intact small mesenteric arteries precontracted with methoxamine
| Abn-cbd | pEC50 | Emax (%) | n |
|---|---|---|---|
| Control | 6.1±0.1 | 93±2 | 8 |
| +AM 281 (1 μM) | 6.0±0.1 | 94±1 | 4 |
| +AM 251 (1 μM) | 5.7±0.1 | 94±2 | 4* |
| Control | 6.2±0.1 | 93±2 | 4 |
| +SR 141716A (200 nM) | 6.1±0.1 | 90±3 | 4 |
| +SR 141716A (1 μM) | 5.3±0.1 | 82±4 | 4* |
| +SR 141716A (3 μM) | 5.2±0.2 | 65±13 | 4* |
| Control | 6.0±0.1 | 96±1 | 6 |
| +SR 144528 (1 μM) | 5.9±0.1 | 84±7 | 6* |
| Control | 5.9±0.2 | 89±4 | 4 |
| +AM 630 (10 μM) | 5.7±0.1 | 91±2 | 4 |
All experiments were performed in the presence of 10 μM indomethacin. Data are expressed as mean±s.e.mean. pEC50 and Emax values were obtained directly from individual log concentration – response curves. n represents the number of animals.
*
Indicates significantly different from control values (two-way analysis of variance; P<0.01).