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. 2003 Apr 25;138(8):1417–1424. doi: 10.1038/sj.bjp.0705175

Figure 5.

Figure 5

Activation and block of mGluRs act on motorneuron intrinsic properties and modulate responses evoked by glutamate, AMPA and NMDA. Currents were measured 15 min after application of ACPD or MCPG. (a) Time course of the mean effect of ACPD on holding currents and conductance (N=8). There is a small but significant decrease in conductance and a shift in holding current in the depolarizing direction which is not significant. (b) Time course of the mean effect of ACPD on glutamate-evoked currents (N=8). The increase in area is stable over the time of application. (c) Activation of mGluR receptors by ACPD enhanced the current area of glutamate-evoked currents by 18.7±6% (left, N=6). Block of mGluR receptors by MCPG decreased current area by 21.6±4% (right, N=8). *Paired t-test, P<0.05. (d) Activation of mGluR receptors by ACPD enhanced area of currents evoked by both NMDA (left, N=5) and AMPA (right, N=5). *Paired t-test, P<0.05.