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Effect of cacospongionolide B on (a) iNOS and (b) COX-2 protein expression in mouse peritoneal macrophages. Cells were preincubated with drugs for 30 min and then stimulated with zymosan for 18 h. B: basal (nonstimulated cells); Z: zymosan; CB: cacospongionolide B; MG: MG-132; Dx: dexamethasone. After densitometric analysis, iNOS and COX-2 expression levels were normalized to β-actin and expressed as mean ± s.e. mean (n=3). **P<0.01; *P<0.05 with respect to Z.
